Annexed villages to metropolises face numerous environmental contaminations. One of the most common contaminations that is of great importance is pollution of soil, waste and .... Accordingly, the present paper analyzes the environmental contaminations of the annexed villages to Mashhad. The research method is descriptive-analytic and ArcGIS and GeoDa software are used for analyzing information. Moran's I and General G-Statistic was used for investigating the spatial distribution of the leishmaniosis, and to measure the spatial autocorrelation of leishmaniosis resulting from environmental contamination, bivariate Moran's I was used. The statistical population consists of 10 annexed villages to Mashhad. We obtained the samples from the statistics of Health Network. Among the studied villages, Cis-Abad village had the highest rate of disease with 2190 cases. The results show that the spatial distribution of leishmaniosis in Mashhad is clustered and G-Statistic is 0.5. In relation to spatial autocorrelation of and environmental contaminations, the obtained spatial distribution was cluster type and, bivariate Moran's I was 0. 68, which indicates that places on which environmental pollution is high are more likely to develop leishmaniosis disease. The results show that since the merged villages in Mashhad are more widely located around the Kashaf Rood river and the direction of the slope of Mashhad is towards this river, the most environmental pollution exist in the merged villages which has resulted in leishmaniosis disease for the inhabitants of these areas.